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Age-related decline in nicotinic receptor availability with [(123)I]5-IA-85380 SPECT

Human postmortem studies have reported decreases with age in high affinity nicotine binding in brain. We investigated the effect of age on β(2)-containing nicotinic acetylcholine receptor (β(2)-nAChR) availability in eight brain regions of living human subjects using the ligand [(123)I]5-IA-85380 ([...

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Detalhes bibliográficos
Main Authors: Mitsis, Effie M., Cosgrove, Kelly P., Staley, Julie K., Bois, Frederic, Frohlich, Erin B., Tamagnan, Gilles D., Estok, Kristina M., Seibyl, John P., van Dyck, Christopher H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523217/
https://ncbi.nlm.nih.gov/pubmed/18242781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2007.12.008
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