Pyrrolysine is not hardwired for cotranslational insertion at UAG codons

Pyrrolysine (Pyl), the 22nd naturally encoded amino acid, gets acylated to its distinctive UAG suppressor tRNA(Pyl) by the cognate pyrrolysyl-tRNA synthetase (PylRS). Here we determine the RNA elements required for recognition and aminoacylation of tRNA(Pyl) in vivo by using the Pyl analog N-ε-cyclo...

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Bibliografske podrobnosti
Main Authors: Ambrogelly, Alexandre, Gundllapalli, Sarath, Herring, Stephanie, Polycarpo, Carla, Frauer, Carina, Söll, Dieter
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805618/
https://ncbi.nlm.nih.gov/pubmed/17360621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611634104
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