The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease

The mechanisms leading to degeneration of dopaminergic neurons (DNs) in the substantia nigra of patients with Parkinson's disease (PD) are not completely understood. Here, we show, in the postmortem human tissue, that these neurons aberrantly express mitosis-associated proteins, including the E...

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Detalhes bibliográficos
Main Authors: Höglinger, Günter U., Breunig, Joshua J., Depboylu, Candan, Rouaux, Caroline, Michel, Patrick P., Alvarez-Fischer, Daniel, Boutillier, Anne-Laurence, DeGregori, James, Oertel, Wolfgang H., Rakic, Pasko, Hirsch, Etienne C., Hunot, Stéphane
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805567/
https://ncbi.nlm.nih.gov/pubmed/17360686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611671104
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