NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1

Toll-like receptors (TLRs)-2 and -4 are important proteins in innate immunity, recognizing microbial products and eliciting host defense responses. Both use the adapter proteins MyD88 and MyD88 adapter-like (Mal) to activate signaling pathways. Here we report that Mal but not MyD88 interacts with ca...

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Bibliografski detalji
Glavni autori: Miggin, Sinead M., Pålsson-McDermott, Eva, Dunne, Aisling, Jefferies, Caroline, Pinteaux, Emmanuel, Banahan, Kathy, Murphy, Caroline, Moynagh, Paul, Yamamoto, Masahiro, Akira, Shizuo, Rothwell, Nancy, Golenbock, Douglas, Fitzgerald, Katherine A., O'Neill, Luke A. J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1805564/
https://ncbi.nlm.nih.gov/pubmed/17360653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608100104
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