Charge and lipophilicity govern the pharmacokinetics of glycopeptide antibiotics.

The pharmacokinetics and urinary excretion of nine glycopeptide antibiotics with diverse pIs (3.8 to 8.5) and lipophilicities were studied. The disposition of the aridicin antibiotics and their hydrolysis products were examined in male CD-1 mice after subcutaneous and intravenous administration and...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Autores principales:	Pitkin, D H, Mico, B A, Sitrin, R D, Nisbet, L J
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1986
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC180410/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2940973/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.29.3.440
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