Charge and lipophilicity govern the pharmacokinetics of glycopeptide antibiotics.

The pharmacokinetics and urinary excretion of nine glycopeptide antibiotics with diverse pIs (3.8 to 8.5) and lipophilicities were studied. The disposition of the aridicin antibiotics and their hydrolysis products were examined in male CD-1 mice after subcutaneous and intravenous administration and...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Pitkin, D H, Mico, B A, Sitrin, R D, Nisbet, L J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1986
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC180410/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2940973/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.29.3.440
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