Imipenem coadministered with cilastatin compared with moxalactam: integration of serum pharmacokinetics and microbiologic activity following single-dose administration to normal volunteers.

We administered 1 g of imipenem along with equal amounts of cilastatin (a dehydropeptidase I inhibitor) or 2 g of moxalactam intravenously over a period of 30 min to six volunteers in a crossover manner 1 week apart. The antibiotic concentrations and pharmacokinetics for each drug were determined an...

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Bibliografiske detaljer
Main Authors: Standiford, H C, Drusano, G L, Bustamante, C I, Rivera, G, Forrest, A, Tatem, B, Leslie, J, Moody, M
Format: Artigo
Sprog:Inglês
Udgivet: 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC180405/
https://ncbi.nlm.nih.gov/pubmed/3459390
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