Imipenem coadministered with cilastatin compared with moxalactam: integration of serum pharmacokinetics and microbiologic activity following single-dose administration to normal volunteers.

We administered 1 g of imipenem along with equal amounts of cilastatin (a dehydropeptidase I inhibitor) or 2 g of moxalactam intravenously over a period of 30 min to six volunteers in a crossover manner 1 week apart. The antibiotic concentrations and pharmacokinetics for each drug were determined an...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Standiford, H C, Drusano, G L, Bustamante, C I, Rivera, G, Forrest, A, Tatem, B, Leslie, J, Moody, M
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1986
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC180405/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3459390/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.29.3.412
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