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The Role of Mitochondrial DNA Mutations in Mammalian Aging
Mitochondrial DNA (mtDNA) accumulates both base-substitution mutations and deletions with aging in several tissues in mammals. Here, we examine the evidence supporting a causative role for mtDNA mutations in mammalian aging. We describe and compare human diseases and mouse models associated with mit...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1802824/ https://ncbi.nlm.nih.gov/pubmed/17319745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0030024 |
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