Atomic force microscopy captures length phenotypes in single proteins
We use single-protein atomic force microscopy techniques to detect length phenotypes in an Ig module. To gain amino acid resolution, we amplify the mechanical features of a single module by engineering polyproteins composed of up to 12 identical repeats. We show that on mechanical unfolding, mutant...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
1999
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18026/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500169/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.20.11288 |
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