Atomic force microscopy captures length phenotypes in single proteins

We use single-protein atomic force microscopy techniques to detect length phenotypes in an Ig module. To gain amino acid resolution, we amplify the mechanical features of a single module by engineering polyproteins composed of up to 12 identical repeats. We show that on mechanical unfolding, mutant...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Carrion-Vazquez, Mariano, Marszalek, Piotr E., Oberhauser, Andres F., Fernandez, Julio M.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1999
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18026/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500169/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.20.11288
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