Mad2 is required for optimal hematopoiesis: Mad2 associates with c-Kit in MO7e cells

Mitotic arrest deficiency 2 (Mad2) is a component of mitotic spindle checkpoint proteins and is essential for accurate chromosome segregation. We investigated a role for Mad2 in hematopoiesis using Mad2-haploinsufficient (Mad2(+/−)) mice. Mad2(+/−) bone marrow (BM) and spleen manifested decreased ab...

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Bibliografiske detaljer
Main Authors: Ito, Shigeki, Mantel, Charlie R., Han, Myung-Kwan, Basu, Sunanda, Fukuda, Seiji, Cooper, Scott, Broxmeyer, Hal E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2007
Fag:
Hematopoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1801064/
https://ncbi.nlm.nih.gov/pubmed/17038523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-06-030841
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