Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation

Molecular mechanisms preserving hematopoietic stem cell (HSC) self-renewal by maintaining a balance between proliferation, differentiation, and other processes are not fully understood. Hyperactivation of the mammalian target of rapamycin (mTOR) pathway, causing sustained proliferative signals, can...

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Bibliographic Details
Main Authors: Campbell, Timothy B., Basu, Sunanda, Hangoc, Giao, Tao, Wen, Broxmeyer, Hal E.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2009
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765676/
https://ncbi.nlm.nih.gov/pubmed/19690340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-12-195214
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