Mouse hematopoietic cell–targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging–like phenotype

Nuclear transcription factor Stat3 is important for proper regulation of hematopoietic stem cell (HSC) and hematopoietic progenitor cell (HPC) proliferation, survival, and cytokine signaling responses. A new, noncanonical role for Stat3 in mitochondrial function has been discovered recently. However...

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Bibliographic Details
Main Authors: Mantel, Charlie, Messina-Graham, Steven, Moh, Akira, Cooper, Scott, Hangoc, Giao, Fu, Xin-Yuan, Broxmeyer, Hal E.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2012
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460681/
https://ncbi.nlm.nih.gov/pubmed/22665934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-404004
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