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Identifying allosteric fluctuation transitions between different protein conformational states as applied to Cyclin Dependent Kinase 2

BACKGROUND: The mechanisms underlying protein function and associated conformational change are dominated by a series of local entropy fluctuations affecting the global structure yet are mediated by only a few key residues. Transitional Dynamic Analysis (TDA) is a new method to detect these changes...

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Detalhes bibliográficos
Main Authors: Gu, Jenny, Bourne, Philip E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1800904/
https://ncbi.nlm.nih.gov/pubmed/17286863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-8-45
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