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p53-Dependent p21 mRNA Elongation Is Impaired when DNA Replication Is Stalled
We have previously reported that when DNA replication is blocked in some human cell lines, p53 is impaired in its ability to induce a subset of its key target genes, including p21(WAF1/CIP1). Here, we investigated the reason for this impairment by comparing the effects of two agents, hydroxyurea (HU...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1800727/ https://ncbi.nlm.nih.gov/pubmed/17158927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01520-06 |
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