Specific Amino Acid Residues in the Basic Helix-Loop-Helix Domain of SRC-3 Are Essential for Its Nuclear Localization and Proteasome-Dependent Turnover

SRC-3/AIB1/ACTR/pCIP/RAC3/TRAM-1 is a primary transcriptional coactivator for the estrogen receptor. Here we report that deletion of the SRC-3 basic helix-loop-helix (bHLH) domain blocks its proteasome-dependent turnover. We further identified two residues (K17 and R18) in the SRC-3 bHLH domain that...

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Main Authors: Li, Chao, Wu, Ray-Chang, Amazit, Larbi, Tsai, Sophia Y., Tsai, Ming-Jer, O'Malley, Bert W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1800725/
https://ncbi.nlm.nih.gov/pubmed/17158932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00336-06
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