SRC-3Δ4 mediates the interaction of EGFR with FAK to promote cell migration

EGF induces signal transduction between EGFR and FAK, and FAK is required for EGF-induced cell migration. It is unknown, however, what factor mediates the interaction between EGFR and FAK and leads to EGF-induced FAK phosphorylation. Here we identify SRC-3Δ4, a splicing isoform of the SRC-3 oncogene...

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Bibliographische Detailangaben
Hauptverfasser: Long, Weiwen, Yi, Ping, Amazit, Larbi, LaMarca, Heather L., Ashcroft, Felicity, Kumar, Rakesh, Mancini, Michael A., Tsai, Sophia Y., Tsai, Ming-Jer, O'Malley, Bert W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824333/
https://ncbi.nlm.nih.gov/pubmed/20159552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.01.004
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