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Kinetics of the interaction of monophosphates of the antiviral nucleosides 2'-fluoro-1-beta-D-arabinofuranosylpyrimidine and (E)-5-(2-bromovinyl)-2'-deoxyuridine with thymidylate kinases from Vero cells and herpes simplex virus types 1 and 2.

The affinities of the monophosphates of 2'-fluoro-5-iodo-1-beta-D-arabinofuranosyluracil and its 5-methyl analog for cellular thymidylate kinase were two or more orders of magnitude greater than for the thymidine-thymidylate kinases from herpes simplex virus types 1 and 2. In contrast, the monophosp...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Principais autores: Chen, M S, Amico, L A, Speelman, D J
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 1984
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC180014/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6083755/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.26.5.778
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