Racial or ethnic differences in allele frequencies of single‐nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis

BACKGROUND: The anti‐folate drug methotrexate (MTX) is commonly used to treat rheumatoid arthritis. OBJECTIVE: To determine the allele frequencies of five common coding single‐nucleotide polymorphisms (SNPs) in the methylenetetrahydrofolate reductase (MTHFR) gene in African‐Americans and Caucasians...

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Main Authors: Hughes, L B, Beasley, T M, Patel, H, Tiwari, H K, Morgan, S L, Baggott, J E, Saag, K G, McNicholl, J, Moreland, L W, Alarcón, G S, Bridges, S L
格式: Artigo
語言:Inglês
出版: BMJ Group 2006
主題:
Extended Report
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1798268/
https://ncbi.nlm.nih.gov/pubmed/16439441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2005.046797
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