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Meta-analysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicity

OBJECTIVE: Methotrexate is an effective therapy for Rheumatoid Arthritis (RA) but is also associated with toxicity. Pharmacogenetics is the systematic evaluation of the role of genetic differences in the efficacy and toxicity of therapeutic interventions. Because the results of small pharmacogenetic...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Fisher, Mark C., Cronstein, Bruce N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673494/
https://ncbi.nlm.nih.gov/pubmed/19208607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3899/jrheum.080576
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