Natural Polymorphisms in the Human Immunodeficiency Virus Type 2 Protease Can Accelerate Time to Development of Resistance to Protease Inhibitors

Human immunodeficiency virus type 2 (HIV-2) contains numerous natural polymorphisms in its protease (PR) gene that are implicated in drug resistance in the case of HIV-1. This study evaluated emergent PR resistance in HIV-2. Three HIV-2 isolates were selected for resistance to amprenavir (APV), nelf...

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Autores principales: Ntemgwa, Michel, Brenner, Bluma G., Oliveira, Maureen, Moisi, Daniela, Wainberg, Mark A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2007
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797771/
https://ncbi.nlm.nih.gov/pubmed/17116674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00870-06
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