Dual Targeting of GyrB and ParE by a Novel Aminobenzimidazole Class of Antibacterial Compounds

A structure-guided drug design approach was used to optimize a novel series of aminobenzimidazoles that inhibit the essential ATPase activities of bacterial DNA gyrase and topoisomerase IV and that show potent activities against a variety of bacterial pathogens. Two such compounds, VRT-125853 and VR...

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Bibliografiske detaljer
Main Authors: Grossman, Trudy H., Bartels, Douglas J., Mullin, Steve, Gross, Christian H., Parsons, Jonathan D., Liao, Yusheng, Grillot, Anne-Laure, Stamos, Dean, Olson, Eric R., Charifson, Paul S., Mani, Nagraj
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2007
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797739/
https://ncbi.nlm.nih.gov/pubmed/17116675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00596-06
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