Tricyclic GyrB/ParE (TriBE) Inhibitors: A New Class of Broad-Spectrum Dual-Targeting Antibacterial Agents

Increasing resistance to every major class of antibiotics and a dearth of novel classes of antibacterial agents in development pipelines has created a dwindling reservoir of treatment options for serious bacterial infections. The bacterial type IIA topoisomerases, DNA gyrase and topoisomerase IV, ar...

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Hlavní autoři: Tari, Leslie W., Li, Xiaoming, Trzoss, Michael, Bensen, Daniel C., Chen, Zhiyong, Lam, Thanh, Zhang, Junhu, Lee, Suk Joong, Hough, Grayson, Phillipson, Doug, Akers-Rodriguez, Suzanne, Cunningham, Mark L., Kwan, Bryan P., Nelson, Kirk J., Castellano, Amanda, Locke, Jeff B., Brown-Driver, Vickie, Murphy, Timothy M., Ong, Voon S., Pillar, Chris M., Shinabarger, Dean L., Nix, Jay, Lightstone, Felice C., Wong, Sergio E., Nguyen, Toan B., Shaw, Karen J., Finn, John
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873466/
https://ncbi.nlm.nih.gov/pubmed/24386374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084409
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