Activity of Ribavirin against Hantaan Virus Correlates with Production of Ribavirin-5′-Triphosphate, Not with Inhibition of IMP Dehydrogenase

Ribavirin (RBV) is a broad-spectrum antiviral agent that inhibits the production of infectious Hantaan virus (HTNV). Although the mechanism of action of RBV against HTNV is not understood, RBV is metabolized in human cells to both RBV-5′-monophosphate, which inhibits IMP dehydrogenase, resulting in...

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Hlavní autoři: Sun, Yanjie, Chung, Dong-Hoon, Chu, Yong-Kyu, Jonsson, Colleen B., Parker, William B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2007
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797647/
https://ncbi.nlm.nih.gov/pubmed/17060520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00790-06
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