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Ribavirin Reveals a Lethal Threshold of Allowable Mutation Frequency for Hantaan Virus
The broad spectrum of antiviral activity of ribavirin (RBV) lies in its ability to inhibit IMP dehydrogenase, which lowers cellular GTP. However, RBV can act as a potent mutagen for some RNA viruses. Previously we have shown a lack of correlation between antiviral activity and GTP repression for Han...
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| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Microbiology (ASM)
2007
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2168817/ https://ncbi.nlm.nih.gov/pubmed/17699579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00874-07 |
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