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Bilayer deformation by the Kv channel voltage sensor domain revealed by self-assembly simulations

Coarse-grained molecular dynamics simulations are used to explore the interaction with a phospholipid bilayer of the voltage sensor (VS) domain and the S4 helix from the archaebacterial voltage-gated potassium (Kv) channel KvAP. Multiple 2-μs self-assembly simulations reveal that the isolated S4 hel...

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Detalhes bibliográficos
Main Authors: Bond, Peter J., Sansom, Mark S. P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797625/
https://ncbi.nlm.nih.gov/pubmed/17301243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606822104
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