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Recognition of Ribonuclease A by 3′–5′-Pyrophosphate-Linked Dinucleotide Inhibitors: A Molecular Dynamics/Continuum Electrostatics Analysis

The proteins of the pancreatic ribonuclease A (RNase A) family catalyze the cleavage of the RNA polymer chain. The development of RNase inhibitors is of significant interest, as some of these compounds may have a therapeutic effect in pathological conditions associated with these proteins. The most...

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Autors principals: Polydoridis, Savvas, Leonidas, Demetres D., Oikonomakos, Nikos G., Archontis, Georgios
Format: Artigo
Idioma:Inglês
Publicat: Biophysical Society 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1796809/
https://ncbi.nlm.nih.gov/pubmed/17142283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.093419
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