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High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors
The crystal structures of bovine pancreatic ribonuclease A (RNase A) in complex with 3′,5′-ADP, 2′,5′-ADP, 5′-ADP, U-2′-p and U-3′-p have been determined at high resolution. The structures reveal that each inhibitor binds differently in the RNase A active site by anchoring a phosphate group in subsi...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2366950/ https://ncbi.nlm.nih.gov/pubmed/14573867 |
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