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Influence of naturally-occurring 5′-pyrophosphate-linked substituents on the binding of adenylic inhibitors to ribonuclease a: An X-ray crystallographic study

Ribonuclease A is the archetype of a functionally diverse superfamily of vertebrate-specific ribonucleases. Inhibitors of its action have potential use in the elucidation of the in vivo roles of these enzymes and in the treatment of pathologies associated therewith. Derivatives of adenosine 5′-pyrop...

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Detalhes bibliográficos
Main Authors: Holloway, Daniel E, Chavali, Gayatri B, Leonidas, Demetres D, Baker, Matthew D, Acharya, K Ravi
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816359/
https://ncbi.nlm.nih.gov/pubmed/19191310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.21158
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