Role for protease activity in visceral pain in irritable bowel syndrome

Mediators involved in the generation of symptoms in patients with irritable bowel syndrome (IBS) are poorly understood. Here we show that colonic biopsy samples from IBS patients release increased levels of proteolytic activity (arginine cleavage) compared to asymptomatic controls. This was dependen...

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Detalhes bibliográficos
Main Authors: Cenac, Nicolas, Andrews, Christopher N., Holzhausen, Marinella, Chapman, Kevin, Cottrell, Graeme, Andrade-Gordon, Patricia, Steinhoff, Martin, Barbara, Giovanni, Beck, Paul, Bunnett, Nigel W., Sharkey, Keith A., Ferraz, Jose Geraldo P., Shaffer, Eldon, Vergnolle, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1794118/
https://ncbi.nlm.nih.gov/pubmed/17304351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29255
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