Role for protease activity in visceral pain in irritable bowel syndrome

Mediators involved in the generation of symptoms in patients with irritable bowel syndrome (IBS) are poorly understood. Here we show that colonic biopsy samples from IBS patients release increased levels of proteolytic activity (arginine cleavage) compared to asymptomatic controls. This was dependen...

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Главные авторы: Cenac, Nicolas, Andrews, Christopher N., Holzhausen, Marinella, Chapman, Kevin, Cottrell, Graeme, Andrade-Gordon, Patricia, Steinhoff, Martin, Barbara, Giovanni, Beck, Paul, Bunnett, Nigel W., Sharkey, Keith A., Ferraz, Jose Geraldo P., Shaffer, Eldon, Vergnolle, Nathalie
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2007
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1794118/
https://ncbi.nlm.nih.gov/pubmed/17304351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29255
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