Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)

Second mitochondria–derived activator of caspases (Smac) promotes apoptosis via activation of caspases. Here we show that a low-molecular-weight Smac mimetic LBW242 induces apoptosis in multiple myeloma (MM) cells resistant to conventional and bortezomib therapies. Examination of purified patient MM...

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Autors principals: Chauhan, Dharminder, Neri, Paola, Velankar, Mugdha, Podar, Klaus, Hideshima, Teru, Fulciniti, Mariateresa, Tassone, Pierfrancesco, Raje, Noopur, Mitsiades, Constantine, Mitsiades, Nicholas, Richardson, Paul, Zawel, Leigh, Tran, Mary, Munshi, Nikhil, Anderson, Kenneth C.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2007
Matèries:
Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785138/
https://ncbi.nlm.nih.gov/pubmed/17032924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-015149
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