Attenuation of phagocytosis of xenogeneic cells by manipulating CD47

Signal regulatory protein α (SIRPα) is a critical immune inhibitory receptor on macrophages, and its interaction with CD47, a ligand for SIRPα, prevents autologous phagocytosis. We hypothesized that interspecies incompatibility of CD47 may contribute to the rejection of xenogeneic cells by macrophag...

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Bibliographic Details
Main Authors: Wang, Hui, VerHalen, Jon, Madariaga, Maria Lucia, Xiang, Shuanglin, Wang, Shumei, Lan, Ping, Oldenborg, Per-Arne, Sykes, Megan, Yang, Yong-Guang
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2007
Subjects:
Transplantation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785095/
https://ncbi.nlm.nih.gov/pubmed/17008545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-019794
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