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SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl

SHP-2 phosphatase forms a stable protein complex with and is heavily tyrosine-phosphorylated by the oncogenic tyrosine kinase Bcr-Abl. However, the role of SHP-2 in Bcr-Abl–mediated leukemogenesis is unclear. In the present report, we provide evidence that SHP-2 is required for hematopoietic cell tr...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Chen, Jing, Yu, Wen-Mei, Daino, Hanako, Broxmeyer, Hal E., Druker, Brian J., Qu, Cheng-Kui
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2007
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785089/
https://ncbi.nlm.nih.gov/pubmed/17003374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-019141
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