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SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl
SHP-2 phosphatase forms a stable protein complex with and is heavily tyrosine-phosphorylated by the oncogenic tyrosine kinase Bcr-Abl. However, the role of SHP-2 in Bcr-Abl–mediated leukemogenesis is unclear. In the present report, we provide evidence that SHP-2 is required for hematopoietic cell tr...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1785089/ https://ncbi.nlm.nih.gov/pubmed/17003374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-019141 |
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