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SHP2 Is Required for BCR-ABL1-Induced Hematologic Neoplasia
BCR-ABL1-targeting tyrosine kinase inhibitors (TKIs) have revolutionized treatment of Philadelphia chromosome-positive (Ph(+)) hematologic neoplasms. Nevertheless, acquired TKI resistance remains a major problem in chronic myeloid leukemia (CML), and TKIs are less effective against Ph(+) B-cell acut...
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| Publicado no: | Leukemia |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6005183/ https://ncbi.nlm.nih.gov/pubmed/28804122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.250 |
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