T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFβ dosage.

The family of core-binding factors includes the DNA-binding subunits Runx1-3 and their common non–DNA-binding partner CBFβ. We examined the collective role of core-binding factors in hematopoiesis with a hypomorphic Cbfb allelic series. Reducing CBFβ levels by 3- or 6-fold caused abnormalities in bo...

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Autors principals: Talebian, Laleh, Li, Zhe, Guo, Yalin, Gaudet, Justin, Speck, Maren E., Sugiyama, Daisuke, Kaur, Prabhjot, Pear, Warren S., Maillard, Ivan, Speck, Nancy A.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2007
Matèries:
Plenary Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785070/
https://ncbi.nlm.nih.gov/pubmed/16940420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-021188
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