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Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specification
CBFβ is the non-DNA binding subunit of the core binding factors (CBFs). Mice with reduced CBFβ levels display profound, early defects in T-cell but not B-cell development. Here we show that CBFβ is also required at very early stages of natural killer (NK)–cell development. We also demonstrate that T...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society of Hematology
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2481540/ https://ncbi.nlm.nih.gov/pubmed/18390836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-120261 |
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