Notch regulates innate lymphoid cell plasticity during human natural killer cell development

Human natural killer (NK) cells develop in tonsils through discrete NK cell developmental intermediates (NKDIs), yet the mechanistic regulation of this process is unclear. We demonstrate that Notch activation in human tonsil-derived stage 3 (CD34(−)CD117(+)CD94(−)NKp80(−)) and 4A (CD34(−)CD117(+/−)C...

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Publicado en:J Immunol
Main Authors: Nalin, Ansel P., Kowalski, Jesse J., Sprague, Alexander C., Schumacher, Blaire K., Gerhardt, Adam G., Youssef, Youssef, Vedantam, Kiran V., Zhang, Xiaoli, Siebel, Christian W., Mace, Emily M., Caligiuri, Michael A., Mundy-Bosse, Bethany L., Freud, Aharon G.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7658047/
https://ncbi.nlm.nih.gov/pubmed/33020148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000434
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