Notch regulates innate lymphoid cell plasticity during human natural killer cell development

Human natural killer (NK) cells develop in tonsils through discrete NK cell developmental intermediates (NKDIs), yet the mechanistic regulation of this process is unclear. We demonstrate that Notch activation in human tonsil-derived stage 3 (CD34(−)CD117(+)CD94(−)NKp80(−)) and 4A (CD34(−)CD117(+/−)C...

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Pubblicato in:J Immunol
Autori principali: Nalin, Ansel P., Kowalski, Jesse J., Sprague, Alexander C., Schumacher, Blaire K., Gerhardt, Adam G., Youssef, Youssef, Vedantam, Kiran V., Zhang, Xiaoli, Siebel, Christian W., Mace, Emily M., Caligiuri, Michael A., Mundy-Bosse, Bethany L., Freud, Aharon G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7658047/
https://ncbi.nlm.nih.gov/pubmed/33020148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000434
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