PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR

The receptor tyrosine kinase/PI3K/Akt/mammalian target of rapamycin (RTK/PI3K/Akt/mTOR) pathway is frequently altered in tumors. Inactivating mutations of either the TSC1 or the TSC2 tumor-suppressor genes cause tuberous sclerosis complex (TSC), a benign tumor syndrome in which there is both hyperac...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhang, Hongbing, Bajraszewski, Natalia, Wu, Erxi, Wang, Hongwei, Moseman, Annie P., Dabora, Sandra L., Griffin, James D., Kwiatkowski, David J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2007
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1784000/
https://ncbi.nlm.nih.gov/pubmed/17290308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28984
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