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Photolabelling the urotensin II receptor reveals distinct agonist- and partial-agonist-binding sites
The mechanism by which GPCRs (G-protein-coupled receptors) undergo activation is believed to involve conformational changes following agonist binding. We have used photoaffinity labelling to identify domains within GPCRs that make contact with various photoreactive ligands in order to better underst...
Shranjeno v:
| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Portland Press Ltd.
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1783990/ https://ncbi.nlm.nih.gov/pubmed/17064254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060943 |
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