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Inferring the Cellular Origin of Voltage and Calcium Alternans from the Spatial Scales of Phase Reversal during Discordant Alternans

Beat-to-beat alternation of the action potential duration (APD) in paced cardiac cells has been linked to the onset of lethal arrhythmias. Both experimental and theoretical studies have shown that alternans at the single cell level can be caused by unstable membrane voltage (V(m)) dynamics linked to...

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Main Authors: Sato, Daisuke, Shiferaw, Yohannes, Qu, Zhilin, Garfinkel, Alan, Weiss, James N., Karma, Alain
Formato: Artigo
Idioma:Inglês
Publicado: Biophysical Society 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783870/
https://ncbi.nlm.nih.gov/pubmed/17172300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.100982
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