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A specific PP2A regulatory subunit, B56γ, mediates DNA damage-induced dephosphorylation of p53 at Thr55

Protein phosphatase 2A (PP2A) has been implicated to exert its tumor suppressive function via a small subset of regulatory subunits. In this study, we reported that the specific B regulatory subunits of PP2A B56γ1 and B56γ3 mediate dephosphorylation of p53 at Thr55. Ablation of the B56γ protein by R...

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Autors principals: Li, Heng-Hong, Cai, Xin, Shouse, Geoffrey P, Piluso, Landon G, Liu, Xuan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783465/
https://ncbi.nlm.nih.gov/pubmed/17245430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601519
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