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Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae
In eukaryotic cells the concentration of dNTP is highest in S phase and lowest in G(1) phase and is controlled by ribonucleotide reductase (RNR). RNR activity is eliminated in all eukaryotes in G(1) phase by a variety of mechanisms: transcriptional regulation, small inhibitory proteins, and protein...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1783093/ https://ncbi.nlm.nih.gov/pubmed/17227840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610585104 |
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