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αβ T-cell development is not affected by inversion of TCRβ gene enhancer sequences: polar enhancement of gene expression regardless of enhancer orientation
V(D)J recombination and expression of the T-cell receptor β (TCRβ) gene are required for the development of the αβ T lymphocyte lineage. These processes depend on a transcriptional enhancer (Eβ) which acts preferentially on adjacent upstream sequences, and has little impact on the 5′ distal and 3′ p...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Blackwell Science Inc
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1783007/ https://ncbi.nlm.nih.gov/pubmed/12871217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2003.01691.x |
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