αβ T-cell development is not affected by inversion of TCRβ gene enhancer sequences: polar enhancement of gene expression regardless of enhancer orientation

V(D)J recombination and expression of the T-cell receptor β (TCRβ) gene are required for the development of the αβ T lymphocyte lineage. These processes depend on a transcriptional enhancer (Eβ) which acts preferentially on adjacent upstream sequences, and has little impact on the 5′ distal and 3′ p...

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Main Authors: Huang, Fang, Cabaud, Olivier, Verthuy, Christophe, Hueber, Anne-Odile, Ferrier, Pierre
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2003
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783007/
https://ncbi.nlm.nih.gov/pubmed/12871217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2567.2003.01691.x
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