Epitope-specific crosslinking of CD45 down-regulates membrane-associated tyrosine phosphatase activity and triggers early signalling events in human activated T cells

CD45 engagement by monoclonal antibodies on human activated T cells triggers tumour necrosis factor-α (TNF-α) gene transcription in an epitope-specific manner. To dissect the early signalling events leading to TNF-α gene expression, we established that CD45 crosslinking resulted in tyrosine phosphor...

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Detalhes bibliográficos
Main Authors: Spertini, François, Perret-Menoud, Veronique, Barbier, Nathalie, Chatila, Talal, Barbey, Catherine, Corthesy, Blaise
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782601/
https://ncbi.nlm.nih.gov/pubmed/15554922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2004.01986.x
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