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An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
MDM2 (HDM2) is a ubiquitin ligase that can target the p53 tumor suppressor protein for degradation. The RING domain is essential for the E3 activity of MDM2, and we show here that the extreme C-terminal tail of MDM2 is also critical for efficient E3 activity. Loss of E3 function in MDM2 mutants dele...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1782374/ https://ncbi.nlm.nih.gov/pubmed/17159902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601469 |
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