載入...

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

MDM2 (HDM2) is a ubiquitin ligase that can target the p53 tumor suppressor protein for degradation. The RING domain is essential for the E3 activity of MDM2, and we show here that the extreme C-terminal tail of MDM2 is also critical for efficient E3 activity. Loss of E3 function in MDM2 mutants dele...

全面介紹

Na minha lista:
書目詳細資料
Main Authors: Uldrijan, Stjepan, Pannekoek, Willem-Jan, Vousden, Karen H
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2007
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782374/
https://ncbi.nlm.nih.gov/pubmed/17159902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601469
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!